I read this research paper some time ago and recently came across some of my notes which has prompted some further research on my part, and a consultation with a dietician I know (thanks Jenn Z).
What I found of interest in the article was that it was a synthesis of many different aspects of the biomedical nature, or current biomedical theories, of autism. The paper also uses a fairly significant list of sources to draw on and is quite broad in its approach yet distills the information down to what the authors think are the salient points.
Some of my notes for further thought and investigation are (as I think they may be relevant to K):
- neuronal cell loss, especially Purkinje cells, due to likely events of ischemia, hypoxia, and cellular edema
- these are the physiological effects purportedly ameliorated by HBOT
- excitotoxicity (seizures, metabolic insufficiencies) can cause neuronal (Purk. cell) loss
- K suffers from seizures, do his earlier test results indicate any metabolic disturbances that could be relevant here and can help reduce neuronal insult?
- G protein dysfunction
- how does this article relate?
- Viral infections
- do we have any testing evidence of viral/chronic viral infections
- vitamin deficiencies
- as relates to K’s earlier test results and our commitment to his vitamin “regime”
- Heavy metal toxicity
- K’s hair analysis (X2) indicate that this may have been an issue
- Chronic malabsorbtion syndrome
- likely very relevant for K as seen in his test results
- gluten/casein sensitivity as well as other markers for intestinal inflammation and poor nutritional absorbtion. (Hence this represents a significant portion of our intervention).
- likely very relevant for K as seen in his test results
- Oxidative Stress information here
and here as well as here. Looking in our documents section for information on HBOT can also provide some information as this is one of the proposed benefits of this treatment method.- Of Purk. cells can be ameliorated by antioxidants, namely Vitamin E and isoindoline nitroxide (Jenn Z to help?).
- Mention of brain volume and head circumference
- K’s MRI report indicated no evidence of increased brain volume though I am cautious about comparing results across studies when this is not the primary focus of the report and the criteria for comparison may not be valid.
- K’s head circumference developmentally/historically and currently?
Quote from the article; “Metal toxicity can cause Purk. cell death and increased brain volume”
- this is likely for K based on his multiple hair analyses and the presence of various heavy metals, but is it significantly high enough to account for some of his issues?
- How does his head size compare over the course of his development to date?
Evidence for glutathione deficiency in ASD kids
- our supplementation with glutathione, both orally and lotion.
- is this sufficient to overcome the deficiency? Jenn Z. question
- cysteine is relevant here, can we supplement without impacting Candida growth by using a form other than NAC?
- very good evidence for the importance of glutathione within the article
Related posts:
- The impact of autism on siblings We have a fairly lengthy article in our repository on the impact on siblings of having an ASD child in the family. Some other articles...
- Autism and Diet: Revisited I was reading a blog that looks at scientific research and autism and came across these 2 posts regarding autism and the GFCF diet. In...
- Immunocal Presentation I recently attended an information session regarding a nutraceutical product and some of the research behind it and its benefits. I must say that initially...
- Road Trip It was time for K to visit his DAN! doctor, who is a naturopath in Vancouver, and that meant it was time for a road...
- Interesting implications for ASD I read this book review on an online media website and my thoughts, as they so often do, turned to implications for ASD and the...
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